MOTS-C 40mg

MOTS-C is a mitochondrial-derived peptide (MDP) encoded by your own mitochondrial DNA that acts as a "mitohormone" — signaling your cells to optimize energy metabolism, enhance insulin sensitivity, and boost exercise performance through AMPK pathway activation.

MECHANISM OF ACTION

MOTS-C operates through the Folate-AICAR-AMPK pathway, inhibiting the folate cycle and leading to AMPK activation. Under metabolic stress, it translocates to the nucleus and binds to stress-response transcription factors (NRF2, ATF1/ATF7) to regulate gene expression involved in metabolism, antioxidant response, and cellular stress adaptation. This allows it to enhance mitochondrial function and metabolic flexibility at the cellular level.

POTENTIAL BENEFITS

• Enhanced insulin sensitivity and improved glucose metabolism

• AMPK pathway activation for metabolic optimization

•Mitochondrial function enhancement

•Exercise performance improvement (12-15% gains in endurance capacity)

•Potential longevity and anti-aging benefits • Improved metabolic flexibility and body composition

• Cellular stress adaptation and antioxidant response support

WHY IT'S BEING RESEARCHED

MOTS-C is being studied because it represents a novel mitohormone that directly addresses metabolic dysfunction at the mitochondrial level. Unlike exogenous hormones, it works through the body's natural AMPK pathway to improve insulin sensitivity, enhance exercise capacity, and support longevity. Research shows it may help with gestational diabetes, type 2 diabetes, and age-related metabolic decline, making it a compelling target for metabolic health and anti-aging research.

INTERESTING FACTS

• Single-dose MOTS-C improved running time by 12% and distance by 15% in untrained mice

• Chronic exercise training increases natural MOTS-C protein expression 1.5-5-fold in muscle tissue

• Serum MOTS-C levels are significantly lower in gestational diabetes patients

• It can translocate from mitochondria to the nucleus during metabolic stress• Encoded by mitochondrial DNA (MT-RNR1 gene) within the 12S rRNA

• Effects typically appear within 1-2 weeks, with maximum benefits by 8-12 weeks

• Works synergistically with exercise and metabolic stress

• Complements SS-31 for dual-pathway mitochondrial support

STACKING

Common research combinations include:

• SS-31 (Elamipretide) for synergistic mitochondrial protection and metabolic enhancement — SS-31 protects mitochondrial structure via cardiolipin targeting while MOTS-C activates AMPK for metabolic regulation, providing complementary mitochondrial support

• NAD+ precursors (NMN, NR) for complementary mitochondrial enhancement

• Resveratrol for synergistic SIRT1/AMPK activation and longevity benefits

• Growth hormone peptides (CJC-1295, Ipamorelin) for metabolic and performance optimization

• Exercise performance protocols combining MOTS-C with pre-workout timing

• Metabolic health stacks focused on insulin sensitivity and glucose control

• Anti-aging longevity programs combining mitochondrial support compounds

RESEARCH PURPOSES ONLY

NOT AVAILABLE FOR HUMAN CONSUMPTION