5-Amino-1MQ
5-Amino-1mq is a small molecule NNMT inhibitor designed to boost cellular NAD+ levels and enhance mitochondrial function. Here's a detailed breakdown:
MECHANISM OF ACTION
5-Amino-1mq works by inhibiting the NNMT enzyme (nicotinamide N-methyltransferase), which normally breaks down NAD+. By blocking this enzyme, the compound preserves NAD+ in cells, supporting mitochondrial energy production, DNA repair, and metabolic processes critical for healthy aging.
POTENTIAL BENEFITS
Enhanced NAD+ levels and mitochondrial function
Improved energy metabolism and cellular repair
Better insulin sensitivity and metabolic rate
Potential longevity and anti-aging effects
Enhanced exercise performance and recovery
Accelerated fat oxidation and body composition improvements
WHY IT'S BEING RESEARCHED
NAD+ naturally declines with age, contributing to mitochondrial dysfunction and metabolic decline.
By preventing NAD+ degradation rather than just supplementing it, 5-Amino-1mq offers a novel approach to maintaining cellular energy and supporting longevity pathways that activate sirtuins and other repair mechanisms.
INTERESTING FACTS
Available in both oral (25-75mg daily) and injectable (150-600mcg daily) forms with different bioavailability profiles
Oral form shows 38.4% bioavailability in animal studies; injectable provides 100% bioavailability
Recent 2024 research showed 40-60% grip strength improvements in aged mice, with no adverse effects
Works synergistically with other NAD+ precursors like NMN and NR
No human clinical trials published yet — all dosing extrapolated from animal research
Expected timeline: energy increases within 1-2 weeks, metabolic changes by weeks 2-4, body composition shifts by weeks 4-8
RESEARCH PURPOSES ONLY
NOT AVAILABLE FOR HUMAN CONSUMPTION

